Regulation of muscle organ development

Across TCGA cell cohorts, RNA activity of the Regulation of muscle organ development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERBB3, SLC52A2, and DHH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERBB3 grouped by Regulation of muscle organ development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ERBB3 →	-0.579	-0.830	<.001	<.001	3	7
BREAST	SLC52A2 →	-0.219	-0.644	<.001	.009	3	6
OVARY	DHH →	-0.428	-1.289	<.001	<.001	3	5
LARGE_INTESTINE	PRAG1 →	-0.136	-0.872	.008	<.001	3	5
OVARY	L1CAM →	-0.264	-0.980	.003	.006	3	5
LIVER	TGFB1 →	-0.158	-1.103	.008	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERBB3 by Regulation of muscle organ development activity — BREAST

Explore this box plot interactively →