Regulation of muscle organ development

Across TCGA cell cohorts, RNA activity of the Regulation of muscle organ development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLLN, FRAT1, and RASSF8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLLN grouped by Regulation of muscle organ development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLLN →	+0.628	+0.419	<.001	<.001	3	4
LUNG_NSCLC_LUSC	FRAT1 →	+0.475	+0.261	.004	.002	3	4
UPPER_AERODIGESTIVE_TRACT	RASSF8 →	-1.608	-0.364	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	LRRC8C →	-2.231	-0.404	.001	.001	3	4
URINARY_TRACT	DMTN →	+3.853	+0.399	.002	<.001	3	3
OVARY	PEX1 →	+0.898	+0.246	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLLN by Regulation of muscle organ development activity — LARGE_INTESTINE

Explore this box plot interactively →