Positive regulation of skeletal muscle tissue growth

Across TCGA cell cohorts, RNA activity of the Positive regulation of skeletal muscle tissue growth pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA0753, SMYD4, and SMUG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIAA0753 grouped by Positive regulation of skeletal muscle tissue growth-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KIAA0753 →	+1.002	+0.244	.008	<.001	3	5
BLOOD_Leukemia	SMYD4 →	+1.031	+0.228	.006	.001	3	4
LUNG_NSCLC_LUAD	SMUG1 →	-0.464	-0.111	.004	.002	3	3
CNS	MYL12A →	-1.440	-0.165	.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	TMC6 →	+2.202	+0.186	.003	.001	3	3
UPPER_AERODIGESTIVE_TRACT	THAP2 →	+0.897	+0.146	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIAA0753 by Positive regulation of skeletal muscle tissue growth activity — BLOOD_Leukemia

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