Myoblast fate commitment

Across TCGA patient cohorts, RNA activity of the Myoblast fate commitment pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINB5, GGH, and POR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast fate commitment activity versus SERPINB5 in BRCA (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINB5 →	+1.095	+0.047	<.001	<.001	3	5
BRCA	GGH →	+0.782	+0.059	<.001	<.001	3	5
UCEC	POR →	+0.428	+0.094	<.001	.003	3	5
BRCA	SNX4_S22 →	+0.450	+0.048	.001	.003	3	4
BRCA	TBC1D4_S666 →	+0.479	+0.039	<.001	<.001	3	4
BRCA	TINAGL1 →	+0.440	+0.038	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048625 vs SERPINB5 — BRCA

Explore this scatter interactively →