Myoblast fate commitment

Across TCGA patient cohorts, RNA activity of the Myoblast fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRAP2, FYB2, and IGF2BP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast fate commitment activity versus MRAP2 in LSCC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MRAP2 →	+1.725	+0.642	<.001	.002	3	4
BRCA	FYB2 →	-1.058	-0.487	<.001	.006	3	4
LSCC	IGF2BP2 →	+0.922	+0.518	.001	.001	3	4
BRCA	TIMP3 →	-1.250	-0.634	<.001	<.001	3	3
LSCC	CCNB1IP1 →	+0.350	+0.510	.006	.002	3	3
LSCC	EFS →	+0.888	+0.724	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048625 vs MRAP2 — LSCC

Explore this scatter interactively →