Myoblast fate commitment

Across TCGA cell cohorts, RNA activity of the Myoblast fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAF7, C19orf73, and NCDN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFAF7 grouped by Myoblast fate commitment-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NDUFAF7 →	-1.107	-1.516	.004	.001	3	4
UPPER_AERODIGESTIVE_TRACT	C19orf73 →	-0.362	-1.346	.004	.002	3	4
OESOPHAGUS	NCDN →	+0.399	+1.447	.006	.005	3	4
SKIN	CRIPT →	-0.693	-1.298	.002	.002	3	4
CNS	RAPGEF5 →	-2.982	-1.886	.003	<.001	3	4
LUNG_SCLC	RGS10 →	-2.707	-1.362	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFAF7 by Myoblast fate commitment activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →