Myoblast fate commitment

Across TCGA cell cohorts, RNA activity of the Myoblast fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPAS1, IFRD1, and TCF7L2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast fate commitment activity versus EPAS1 in BONE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	EPAS1 →	+3.324	+0.145	<.001	<.001	3	15
BONE	IFRD1 →	+1.012	+0.170	.003	.001	3	11
STOMACH	TCF7L2 →	+2.227	+0.222	<.001	<.001	3	10
BREAST	APOL6 →	+1.894	+0.107	<.001	.006	3	8
OESOPHAGUS	TNFRSF21 →	+1.871	+0.122	<.001	.005	3	8
BONE	POLD4 →	+2.157	+0.198	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048625 vs EPAS1 — BONE

Explore this scatter interactively →