Embryonic camera-type eye morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic camera-type eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM32, FAM161B, and CDH24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAM32 grouped by Embryonic camera-type eye morphogenesis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ADAM32 →	-0.534	-1.146	<.001	.002	3	4
LUNG_NSCLC_LUAD	FAM161B →	-0.587	-0.965	<.001	<.001	3	4
KIDNEY	CDH24 →	-0.909	-0.844	.002	.001	3	3
KIDNEY	GRAMD1B →	-1.970	-1.114	.004	.002	3	3
LIVER	TMED8 →	-0.411	-0.827	.002	.001	3	3
LIVER	DNM1 →	-2.796	-0.853	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAM32 by Embryonic camera-type eye morphogenesis activity — OESOPHAGUS

Explore this box plot interactively →