Embryonic camera-type eye morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic camera-type eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM225B, OSTC, and PICK1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic camera-type eye morphogenesis activity versus TMEM225B in BLOOD_Leukemia (Pearson r = 0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM225B →	+2.590	+0.786	.007	.009	3	3
OESOPHAGUS	OSTC →	-1.304	-0.633	.009	.003	3	3
BREAST	PICK1 →	+0.946	+1.060	.004	.007	3	3
OESOPHAGUS	RAB19 →	+0.930	+0.578	.001	<.001	3	2
OESOPHAGUS	VPS51 →	+1.085	+0.564	.007	<.001	3	2
OESOPHAGUS	DHRS1 →	+0.710	+0.578	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048596 vs TMEM225B — BLOOD_Leukemia

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