Eye morphogenesis

Across TCGA patient cohorts, RNA activity of the Eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF14, CCNB1, and KIF2C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eye morphogenesis activity versus KIF14 in OV (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KIF14 →	-0.709	-0.675	.003	.003	3	4
OV	CCNB1 →	-0.994	-0.728	<.001	.003	3	4
OV	KIF2C →	-1.187	-0.702	<.001	.006	3	4
OV	PTTG1 →	-1.281	-0.824	<.001	<.001	3	4
OV	DEPDC1 →	-0.912	-0.775	<.001	<.001	3	4
BRCA	CDC20 →	-0.803	-0.540	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048592 vs KIF14 — OV

Explore this scatter interactively →