Eye morphogenesis

Across TCGA cell cohorts, RNA activity of the Eye morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD5, IHH, and VAPB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FZD5 grouped by Eye morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FZD5 →	-0.390	-1.434	<.001	.001	3	5
LUNG_NSCLC_LUAD	IHH →	-0.185	-0.779	.006	<.001	3	5
BLOOD_Myeloma	VAPB →	-0.370	-1.793	.003	<.001	3	5
CNS	PRDM1 →	-0.225	-0.863	.002	<.001	3	5
CNS	RAB21 →	-0.349	-1.103	<.001	<.001	3	5
OVARY	CDKN2B →	-0.211	-0.693	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FZD5 by Eye morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →