Eye morphogenesis

Across TCGA cell cohorts, RNA activity of the Eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK2A1, PPDPF, and SLC10A7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSNK2A1 grouped by Eye morphogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CSNK2A1 →	+0.799	+1.195	.008	<.001	3	5
CNS	PPDPF →	-1.058	-0.802	<.001	<.001	3	5
LARGE_INTESTINE	SLC10A7 →	+0.744	+0.914	<.001	<.001	3	4
BONE	ANAPC1 →	+1.067	+1.544	<.001	.001	3	4
BLOOD_Leukemia	KLRG1 →	+1.420	+1.027	.002	.003	3	4
OVARY	USF1 →	-0.577	-1.070	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSNK2A1 by Eye morphogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →