Eye morphogenesis

Across TCGA cell cohorts, RNA activity of the Eye morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCK1, ZBTB2, and SPATS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCK1 grouped by Eye morphogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PCK1 →	+0.195	+0.051	.001	.001	3	5
SOFT_TISSUE	ZBTB2 →	+0.189	+0.043	.006	.008	3	5
BREAST	SPATS1 →	+0.328	+0.033	<.001	.002	3	4
LUNG_SCLC	LGALS4 →	+0.207	+0.054	.005	.007	3	4
URINARY_TRACT	IRX4 →	-0.249	-0.075	.009	.001	3	4
BONE	GLUD1 →	+0.221	+0.058	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCK1 by Eye morphogenesis activity — LUNG_SCLC

Explore this box plot interactively →