Developmental cell growth

Across TCGA patient cohorts, RNA activity of the Developmental cell growth pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, C1S, and MMP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Developmental cell growth activity versus TIMP2 in CCRCC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TIMP2 →	+0.552	+0.030	.002	<.001	3	8
OV	C1S →	+0.694	+0.044	<.001	<.001	3	7
OV	MMP2 →	+0.658	+0.039	.006	<.001	2	8
CCRCC	FRZB →	+1.219	+0.031	<.001	<.001	3	7
BRCA	RAI14 →	+0.358	+0.020	<.001	<.001	3	7
OV	ROR2 →	+0.495	+0.038	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048588 vs TIMP2 — CCRCC

Explore this scatter interactively →