Obsolete post-embryonic animal organ morphogenesis

pathway activity — cross-omics
GO:0048563Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete post-embryonic animal organ morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNPY4, RUNX2_S28, and PDLIM3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCNPY4 →+0.512+0.138<.001<.00139
GBMRUNX2_S28 →+0.877+0.082<.001<.00138
UCECPDLIM3 →+0.935+0.124.001<.00138
OVPLAU →+0.647+0.064<.001<.00138
OVSERPINH1 →+0.550+0.068<.001<.00138
BRCAVCL_S795 →+0.620+0.073<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration