Obsolete post-embryonic animal organ morphogenesis

pathway activity — cross-omics
GO:0048563Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete post-embryonic animal organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFRP2, FBLN2, and HSPA7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMSFRP2 →+2.028+0.196<.001<.00135
OVFBLN2 →+2.050+0.202<.001<.00135
GBMHSPA7 →+1.242+0.164.001<.00135
GBMGPR1 →+0.476+0.099.006.00534
GBMCOL1A1 →+2.727+0.173<.001<.00134
BRCAITGA11 →+0.995+0.166.003.00234
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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