Obsolete post-embryonic animal organ morphogenesis

pathway activity — cross-omics
GO:0048563Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete post-embryonic animal organ morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EMILIN1, FBN1_S2702, and ISLR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVEMILIN1 →+0.743+0.198<.001<.00136
OVFBN1_S2702 →+1.246+0.179<.001<.00135
OVISLR →+0.887+0.254<.001<.00135
OVPLEKHO2_S390 →+0.909+0.168<.001<.00135
GBMCOL1A1 →+0.820+0.146<.001<.00134
GBMCOL3A1 →+0.778+0.124<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration