Embryonic organ morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMNN, SERPINB6, and WNK4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic organ morphogenesis activity versus GMNN in COAD (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GMNN →	-0.558	-0.533	.002	.002	3	2
COAD	SERPINB6 →	-0.464	-0.468	.008	.009	3	2
COAD	WNK4 →	+0.898	+0.626	.001	<.001	3	2
COAD	COQ3 →	-0.595	-0.755	<.001	<.001	3	2
COAD	PPIL1 →	-0.518	-0.831	<.001	.001	3	2
COAD	TAF4B →	-0.409	-0.605	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048562 vs GMNN — COAD

Explore this scatter interactively →