Embryonic organ morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NKX2-8, RYR1, and TMEM40, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic organ morphogenesis activity versus NKX2-8 in LUNG_NSCLC_LUSC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NKX2-8 →	-0.615	-0.043	.004	.001	2	8
LARGE_INTESTINE	RYR1 →	-0.891	-0.040	.003	<.001	3	7
LARGE_INTESTINE	TMEM40 →	-0.909	-0.026	.001	.001	3	6
LUNG_NSCLC_LUSC	FBXO27 →	-2.121	-0.044	<.001	<.001	1	8
BLOOD_Lymphoma	GATM →	-2.377	-0.034	<.001	<.001	3	6
BLOOD_Leukemia	MPRIP →	+1.067	+0.029	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048562 vs NKX2-8 — LUNG_NSCLC_LUSC

Explore this scatter interactively →