Embryonic organ morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLGN2, FLNA, and TEAD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic organ morphogenesis activity versus NLGN2 in LUNG_NSCLC_LUAD (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NLGN2 →	-0.926	-0.174	.001	.001	3	6
BLOOD_Lymphoma	FLNA →	-2.051	-0.321	<.001	<.001	3	5
CNS	TEAD2 →	-1.937	-0.297	.001	.002	3	5
BLOOD_Myeloma	SEC24A →	-0.968	-0.293	.007	.004	3	5
PANCREAS	P3H1 →	-1.338	-0.324	.002	.008	3	5
STOMACH	TPST1 →	-2.937	-0.370	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048562 vs NLGN2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →