Negative regulation of pinocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of pinocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCD1, NR1H3_S198, and FGD2_S48, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of pinocytosis activity versus SMARCD1 in OV (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMARCD1 →	-0.426	-0.081	.009	<.001	3	5
UCEC	NR1H3_S198 →	+0.473	+0.154	.006	.002	2	6
PDAC	FGD2_S48 →	+0.455	+0.090	.004	.008	3	5
LSCC	SAMSN1_S107 →	+0.655	+0.104	<.001	<.001	3	4
LSCC	SGF29 →	-0.309	-0.104	<.001	<.001	3	4
HNSC	TAP2 →	+0.425	+0.063	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048550 vs SMARCD1 — OV

Explore this scatter interactively →