Negative regulation of pinocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of pinocytosis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU4-14P, DIPK2B, and ROBO4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of pinocytosis activity versus RNU4-14P in PDAC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RNU4-14P →	-0.468	-0.533	<.001	.006	3	4
UCEC	DIPK2B →	+0.770	+0.477	<.001	.004	3	4
BRCA	ROBO4 →	+0.524	+0.388	<.001	.001	3	4
GBM	PHYHIP →	+1.160	+0.235	.003	<.001	3	4
BRCA	PDE2A →	+0.665	+0.514	<.001	<.001	3	4
GBM	SPATA41 →	+0.198	+0.189	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048550 vs RNU4-14P — PDAC

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