Digestive tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Digestive tract morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRMP1, EIF2S2, and LARP4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Digestive tract morphogenesis activity versus CRMP1 in COAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CRMP1 →	+0.542	+0.028	<.001	.003	3	7
BRCA	EIF2S2 →	-0.201	-0.032	<.001	<.001	3	6
COAD	LARP4 →	-0.304	-0.030	<.001	.002	3	6
GBM	APOBR →	-0.420	-0.036	<.001	.006	3	6
LSCC	SKAP2 →	-0.316	-0.052	<.001	<.001	3	6
LSCC	STK10 →	-0.371	-0.070	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048546 vs CRMP1 — COAD

Explore this scatter interactively →