Digestive tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Digestive tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMTC4, PSME4, and NNMT, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMTC4 grouped by Digestive tract morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMTC4 →	-0.727	-0.423	.001	.002	3	3
LARGE_INTESTINE	PSME4 →	+0.446	+0.828	.009	.002	3	3
OVARY	NNMT →	-4.143	-1.058	.002	<.001	3	3
CNS	LANCL1 →	-0.629	-0.872	.001	.001	3	3
CNS	CSKMT →	+0.987	+1.001	.003	.002	3	3
OESOPHAGUS	CCDC96 →	-0.608	-0.958	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMTC4 by Digestive tract morphogenesis activity — BREAST

Explore this box plot interactively →