Digestive tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Digestive tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABL2, ETS1, and MYBL1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Digestive tract morphogenesis activity versus ABL2 in URINARY_TRACT (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ABL2 →	-1.854	-0.107	<.001	.005	3	12
BREAST	ETS1 →	-2.148	-0.164	<.001	<.001	3	11
BLOOD_Lymphoma	MYBL1 →	-1.340	-0.078	.008	.008	2	12
STOMACH	SNAPC1 →	-1.631	-0.199	<.001	<.001	3	10
OVARY	DKK3 →	-2.809	-0.157	.002	<.001	3	10
LUNG_NSCLC_LUAD	AZIN2 →	-1.079	-0.150	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048546 vs ABL2 — URINARY_TRACT

Explore this scatter interactively →