Bone marrow development

Across TCGA patient cohorts, RNA activity of the Bone marrow development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD300A, GK-AS1, and CSF3R, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone marrow development activity versus CD300A in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD300A →	+0.516	+0.348	<.001	.001	3	6
LSCC	GK-AS1 →	+0.733	+0.463	<.001	<.001	3	6
GBM	CSF3R →	+0.786	+0.279	.001	.008	3	5
GBM	SIGLEC9 →	+0.632	+0.254	.003	.002	2	6
CCRCC	PIK3R5 →	+0.456	+0.158	.004	.003	3	5
CCRCC	PLA2G7 →	+0.676	+0.103	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048539 vs CD300A — LSCC

Explore this scatter interactively →