Bone marrow development

Across TCGA patient cohorts, RNA activity of the Bone marrow development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TP53_S315, SKAP2, and APOBR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone marrow development activity versus TP53_S315 in OV (Pearson r = 0.84).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TP53_S315 →	+1.948	+0.494	<.001	<.001	3	6
GBM	SKAP2 →	+0.461	+0.363	<.001	<.001	3	5
PDAC	APOBR →	+0.416	+0.180	<.001	<.001	3	4
OV	TP53 →	+1.564	+0.435	<.001	<.001	3	4
CCRCC	NCF2 →	+0.532	+0.222	<.001	<.001	3	4
GBM	NCKAP1L →	+0.698	+0.231	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048539 vs TP53_S315 — OV

Explore this scatter interactively →