Bone marrow development

Across TCGA cell cohorts, RNA activity of the Bone marrow development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDB2, CDKN1A, and EDA2R, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDB2 grouped by Bone marrow development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DDB2 →	-1.460	-2.138	<.001	<.001	3	9
SKIN	CDKN1A →	-2.777	-1.576	<.001	<.001	3	8
SKIN	EDA2R →	-2.172	-1.690	<.001	<.001	3	8
SKIN	RRM2B →	-1.428	-1.658	<.001	<.001	3	8
LARGE_INTESTINE	MDM2 →	-1.724	-1.611	<.001	<.001	3	7
SKIN	ACTA2 →	-2.473	-1.626	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDB2 by Bone marrow development activity — SKIN

Explore this box plot interactively →