Bone marrow development

Across TCGA cell cohorts, RNA activity of the Bone marrow development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMCC1, MYNN, and SCN8A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone marrow development activity versus TMCC1 in CNS (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TMCC1 →	-1.100	-0.362	.004	.002	3	3
LUNG_SCLC	MYNN →	-0.377	-0.341	.002	.006	3	3
LUNG_NSCLC_LUAD	SCN8A →	-0.811	-0.396	.008	.003	3	3
CNS	PARD3B →	-0.558	-0.267	.004	.002	3	2
CNS	PHF20L1 →	-0.647	-0.277	<.001	.001	3	2
CNS	DNAJC13 →	-1.473	-0.401	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048539 vs TMCC1 — CNS

Explore this scatter interactively →