Thymus development

Across TCGA patient cohorts, RNA activity of the Thymus development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STRBP, NIPBL, and SMC1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thymus development activity versus STRBP in HNSC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	STRBP →	+0.508	+0.052	<.001	<.001	3	7
LSCC	NIPBL →	+0.254	+0.056	.006	<.001	3	6
LSCC	SMC1A →	+0.166	+0.041	.001	<.001	3	6
HNSC	FHOD1 →	-0.304	-0.061	<.001	.001	3	6
LSCC	MSN →	-0.483	-0.048	<.001	<.001	3	6
BRCA	ANXA1 →	-0.408	-0.039	.008	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048538 vs STRBP — HNSC

Explore this scatter interactively →