Thymus development

Across TCGA patient cohorts, RNA activity of the Thymus development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB7C, RBMS3, and MIR27B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thymus development activity versus ZBTB7C in HNSC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZBTB7C →	+0.904	+0.553	<.001	<.001	3	4
OV	RBMS3 →	+0.604	+0.125	.001	.003	3	3
OV	MIR27B →	+1.167	+0.081	.003	.007	3	3
OV	LINC02748 →	+0.053	+0.113	.002	.004	3	3
COAD	SMIM10L2B →	+0.235	+0.646	.004	.001	3	3
GBM	ALG2 →	+0.252	+0.177	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048538 vs ZBTB7C — HNSC

Explore this scatter interactively →