Thymus development

Across TCGA cell cohorts, RNA activity of the Thymus development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS3, ITPA, and MRPS23, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thymus development activity versus OAS3 in LUNG_SCLC (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OAS3 →	-3.733	-1.636	.001	<.001	3	3
LUNG_SCLC	ITPA →	+0.575	+1.304	<.001	<.001	3	3
LUNG_SCLC	MRPS23 →	+0.928	+1.304	<.001	<.001	3	3
LUNG_SCLC	AGA →	-1.603	-1.675	<.001	<.001	3	3
BLOOD_Lymphoma	TMEM198 →	-1.336	-1.737	<.001	<.001	3	3
LARGE_INTESTINE	TUBGCP6 →	+0.636	+1.565	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048538 vs OAS3 — LUNG_SCLC

Explore this scatter interactively →