Mucosa-associated lymphoid tissue development

Across TCGA patient cohorts, RNA activity of the Mucosa-associated lymphoid tissue development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARP1, RCN3, and TPM4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mucosa-associated lymphoid tissue development activity versus PARP1 in BRCA (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PARP1 →	+0.270	+0.056	.005	.004	3	6
COAD	RCN3 →	-0.604	-0.053	<.001	<.001	3	5
BRCA	TPM4 →	-0.343	-0.051	.004	.002	3	5
BRCA	CNN3 →	-0.414	-0.083	.009	<.001	3	5
BRCA	JCAD_S1044 →	-0.417	-0.053	.009	.008	3	5
COAD	ANTXR1_S563 →	-0.513	-0.056	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048537 vs PARP1 — BRCA

Explore this scatter interactively →