Mucosa-associated lymphoid tissue development

pathway activity — cross-omics
GO:0048537Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mucosa-associated lymphoid tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAA2, STAT5B, and TRAJ48, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADSAA2 →+1.178+0.446.001.00234
HNSCSTAT5B →+0.471+0.135<.001.00134
HNSCTRAJ48 →+1.184+0.147.008.00134
GBMTNS3 →-0.681-0.459.006.00133
GBMSATB2-AS1 →+0.592+0.448<.001.00933
HNSCFAM184A →+0.722+0.150<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration