Spleen development

Across TCGA patient cohorts, RNA activity of the Spleen development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDCD4, TANC2, and ELOB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spleen development activity versus PDCD4 in PDAC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PDCD4 →	+0.293	+0.035	<.001	<.001	3	6
HNSC	TANC2 →	-0.351	-0.042	<.001	.004	3	5
LUAD	ELOB →	-0.109	-0.030	<.001	.002	3	5
GBM	GPRIN3 →	+0.495	+0.055	<.001	<.001	3	5
BRCA	MDM1_S601 →	+0.490	+0.039	<.001	.001	3	5
LUAD	METAP1 →	-0.148	-0.031	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048536 vs PDCD4 — PDAC

Explore this scatter interactively →