Spleen development

Across TCGA patient cohorts, RNA activity of the Spleen development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APC_S2260, RRP8_S223, and RBMS1_S38, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spleen development activity versus APC_S2260 in OV (Pearson r = -0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	APC_S2260 →	+0.907	+0.434	<.001	.001	3	3
LUAD	RRP8_S223 →	+0.479	+0.861	<.001	<.001	3	3
OV	RBMS1_S38 →	+1.745	+0.339	<.001	<.001	3	3
OV	UBA6_S36 →	-1.267	-0.846	.001	.004	2	4
LUAD	HNRNPC_S260 →	+0.272	+0.883	<.001	<.001	3	3
LUAD	RSF1_S1282 →	+0.823	+0.615	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048536 vs APC_S2260 — OV

Explore this scatter interactively →