Lymph node development

Across TCGA patient cohorts, RNA activity of the Lymph node development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INHBA, FAP, and RMDN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymph node development activity versus INHBA in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	INHBA →	+0.867	+0.422	<.001	.006	2	6
LSCC	FAP →	+0.804	+0.553	<.001	.002	3	5
UCEC	RMDN2 →	+0.523	+0.680	.001	.001	3	4
LSCC	PCDH7 →	+0.968	+0.512	.004	.008	3	4
BRCA	ENHO →	-0.995	-0.705	<.001	.001	3	4
PDAC	CALD1 →	+0.379	+0.379	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048535 vs INHBA — LSCC

Explore this scatter interactively →