Lymph node development

Across TCGA patient cohorts, RNA activity of the Lymph node development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2_S159, HDAC1_S409, and LIN9_S325, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymph node development activity versus FERMT2_S159 in OV (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FERMT2_S159 →	+1.050	+1.010	<.001	<.001	3	3
OV	HDAC1_S409 →	-1.175	-0.868	<.001	<.001	3	3
OV	LIN9_S325 →	-1.250	-1.339	<.001	<.001	3	3
COAD	SPEN_S1278 →	-0.749	-0.899	<.001	.001	3	2
OV	AUTS2_T1238 →	-0.939	-0.848	<.001	.001	3	2
HNSC	U2AF2_T126 →	+1.021	+1.333	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048535 vs FERMT2_S159 — OV

Explore this scatter interactively →