Hematopoietic or lymphoid organ development

Across TCGA patient cohorts, RNA activity of the Hematopoietic or lymphoid organ development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3KBP1, TACC1, and CD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic or lymphoid organ development activity versus SH3KBP1 in GBM (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SH3KBP1 →	+0.230	+0.024	.005	.005	3	5
GBM	TACC1 →	+0.214	+0.025	<.001	.002	3	5
GBM	CD4 →	+0.419	+0.023	<.001	<.001	3	5
GBM	CLIC2 →	+0.397	+0.028	.005	<.001	3	5
GBM	ELMO1 →	+0.367	+0.023	<.001	<.001	3	5
BRCA	EVL →	+0.443	+0.028	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048534 vs SH3KBP1 — GBM

Explore this scatter interactively →