Hematopoietic or lymphoid organ development

Across TCGA patient cohorts, RNA activity of the Hematopoietic or lymphoid organ development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB11FIP4, SNORD104, and SPTY2D1OS, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic or lymphoid organ development activity versus RAB11FIP4 in GBM (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAB11FIP4 →	-0.651	-0.121	.001	.003	3	3
GBM	SNORD104 →	+0.497	+0.196	.002	<.001	3	3
GBM	SPTY2D1OS →	+0.235	+0.118	.002	.004	3	3
LSCC	MAPK1IP1L →	+0.296	+0.193	.001	.007	3	2
LSCC	EEF1E1P1 →	+0.490	+0.160	.003	.003	2	3
BRCA	PRELID3B →	-0.374	-0.213	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048534 vs RAB11FIP4 — GBM

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