Hematopoietic or lymphoid organ development

Across TCGA cell cohorts, RNA activity of the Hematopoietic or lymphoid organ development pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR33, NUDT1, and FGD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR33 grouped by Hematopoietic or lymphoid organ development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	WDR33 →	+0.241	+0.193	.001	.002	3	5
OVARY	NUDT1 →	-0.212	-0.976	<.001	.005	3	4
LARGE_INTESTINE	FGD4 →	+0.135	+0.277	.002	.001	3	4
KIDNEY	ATG14 →	-0.292	-1.424	.007	.002	3	4
PANCREAS	TRIO →	+0.153	+0.151	.001	.003	3	4
KIDNEY	CNOT4 →	-0.235	-0.985	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR33 by Hematopoietic or lymphoid organ development activity — OESOPHAGUS

Explore this box plot interactively →