Hematopoietic or lymphoid organ development

Across TCGA cell cohorts, RNA activity of the Hematopoietic or lymphoid organ development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TM9SF1, SPECC1, and REEP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic or lymphoid organ development activity versus TM9SF1 in SOFT_TISSUE (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TM9SF1 →	-0.678	-1.055	.001	.001	3	4
STOMACH	SPECC1 →	-2.145	-1.083	.005	.006	3	4
STOMACH	REEP3 →	-1.029	-0.802	.007	.004	3	4
LUNG_NSCLC_LUSC	ACAA2 →	+3.365	+1.572	.005	.006	3	3
LUNG_NSCLC_LUSC	OLR1 →	-1.805	-1.502	<.001	.005	3	3
SOFT_TISSUE	SRP54 →	-0.418	-1.131	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048534 vs TM9SF1 — SOFT_TISSUE

Explore this scatter interactively →