Negative regulation of viral process

Across TCGA patient cohorts, RNA activity of the Negative regulation of viral process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPSTI1, IL2RA, and OAS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral process activity versus EPSTI1 in BRCA (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EPSTI1 →	+1.131	+0.271	<.001	<.001	3	7
PDAC	IL2RA →	+0.638	+0.184	.001	.006	2	8
OV	OAS2 →	+1.008	+0.140	<.001	<.001	3	6
OV	OAS3 →	+1.870	+0.194	<.001	<.001	3	6
BRCA	CD80 →	+0.757	+0.243	<.001	<.001	3	6
BRCA	NMI →	+0.849	+0.238	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048525 vs EPSTI1 — BRCA

Explore this scatter interactively →