Positive regulation of viral process

Across TCGA cell cohorts, RNA activity of the Positive regulation of viral process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POGLUT2, FCRLA, and BEX3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POGLUT2 grouped by Positive regulation of viral process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	POGLUT2 →	-1.913	-0.189	.008	.005	3	6
SKIN	FCRLA →	+1.397	+0.158	.005	<.001	3	4
CNS	BEX3 →	-0.797	-0.196	.003	.001	3	4
BLOOD_Myeloma	XPNPEP1 →	-1.349	-0.191	.006	.003	3	4
PANCREAS	CUTC →	-0.986	-0.138	<.001	.005	2	5
PANCREAS	PCED1A →	-0.864	-0.145	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POGLUT2 by Positive regulation of viral process activity — STOMACH

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