Positive regulation of viral process

Across TCGA cell cohorts, RNA activity of the Positive regulation of viral process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18B, DLX4, and COPRS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of viral process activity versus KIF18B in LARGE_INTESTINE (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KIF18B →	+0.584	+0.134	.002	.004	3	7
LUNG_NSCLC_LUSC	DLX4 →	+2.362	+0.232	.004	.006	3	7
PANCREAS	COPRS →	+1.048	+0.359	.003	<.001	2	7
BLOOD_Leukemia	DZIP1L →	+1.148	+0.094	.001	.006	2	7
LARGE_INTESTINE	KIF3A →	+0.888	+0.201	<.001	.006	3	6
STOMACH	ZNF573 →	+1.075	+0.274	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048524 vs KIF18B — LARGE_INTESTINE

Explore this scatter interactively →