Negative regulation of behavior

Across TCGA patient cohorts, RNA activity of the Negative regulation of behavior pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A17, UGGT1, and TICRR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of behavior activity versus SLC25A17 in LSCC (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC25A17 →	-0.407	-1.050	<.001	<.001	3	5
LSCC	UGGT1 →	-0.340	-0.937	<.001	<.001	3	5
LSCC	TICRR →	-0.709	-0.742	.001	.005	3	5
GBM	BCL2A1 →	+1.198	+0.284	<.001	.004	3	5
GBM	FCGR3B →	+0.766	+0.205	<.001	.002	3	5
LSCC	HMGXB4 →	-0.543	-1.003	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048521 vs SLC25A17 — LSCC

Explore this scatter interactively →