Negative regulation of behavior

Across TCGA cell cohorts, RNA activity of the Negative regulation of behavior pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARD16, AGTPBP1, and GSTM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CARD16 grouped by Negative regulation of behavior-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CARD16 →	-2.818	-1.090	.003	<.001	3	5
LUNG_NSCLC_LUSC	AGTPBP1 →	-0.683	-1.036	.006	.004	3	4
LUNG_NSCLC_LUAD	GSTM2 →	-1.800	-1.066	.001	<.001	3	4
BLOOD_Leukemia	ABHD1 →	+0.666	+1.227	.001	.004	3	4
CNS	GAREM2 →	+0.681	+0.964	.001	<.001	3	4
OESOPHAGUS	AIFM3 →	+1.417	+0.946	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CARD16 by Negative regulation of behavior activity — SOFT_TISSUE

Explore this box plot interactively →