Positive regulation of behavior

Across TCGA patient cohorts, RNA activity of the Positive regulation of behavior pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ECM2_S213, CHPF, and COL5A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of behavior activity versus ECM2_S213 in LUAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ECM2_S213 →	+0.575	+0.045	<.001	.004	3	5
LUAD	CHPF →	+0.333	+0.052	<.001	<.001	3	5
LSCC	COL5A2 →	+0.579	+0.047	<.001	.002	3	5
GBM	CTHRC1 →	+0.759	+0.053	<.001	<.001	3	5
LUAD	FAP →	+0.587	+0.057	<.001	<.001	3	5
GBM	IQGAP1 →	+0.409	+0.052	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048520 vs ECM2_S213 — LUAD

Explore this scatter interactively →