Positive regulation of behavior

Across TCGA patient cohorts, RNA activity of the Positive regulation of behavior pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPA1P76, MYOM1, and PIP5K1B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of behavior activity versus HNRNPA1P76 in COAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HNRNPA1P76 →	-0.052	-0.949	.004	<.001	3	3
GBM	MYOM1 →	+0.649	+0.540	<.001	.002	3	3
GBM	PIP5K1B →	+0.682	+0.572	<.001	.004	3	3
UCEC	PPP3CB →	+0.392	+0.584	<.001	.007	3	3
GBM	SEPTIN4 →	+1.021	+0.700	<.001	<.001	3	3
GBM	TRIM2 →	+0.626	+0.583	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048520 vs HNRNPA1P76 — COAD

Explore this scatter interactively →