Positive regulation of behavior

Across TCGA cell cohorts, RNA activity of the Positive regulation of behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PABPC1L2B, ZNF76, and RXFP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PABPC1L2B grouped by Positive regulation of behavior-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PABPC1L2B →	-0.493	-0.306	.001	.006	3	3
BLOOD_Lymphoma	ZNF76 →	-0.420	-0.224	.006	.009	3	3
KIDNEY	RXFP1 →	-0.190	-0.335	.003	.002	3	3
BLOOD_Myeloma	PHF14 →	+0.237	+0.242	<.001	.009	2	3
BLOOD_Lymphoma	SFRP4 →	+0.241	+0.238	.001	.003	3	2
BLOOD_Lymphoma	CCL2 →	-0.540	-0.321	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PABPC1L2B by Positive regulation of behavior activity — BLOOD_Lymphoma

Explore this box plot interactively →